Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes.
نویسندگان
چکیده
Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
منابع مشابه
Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes† †Electronic supplementary information (ESI) available: Notes on mixed halide–triflate heterocycles and details of the Pfizer RKB and CAS Scifinder® searches. See DOI: 10.1039/c6sc02118b Click here for additional data file.
Substituted heteroarenes form the core of numerous pharmacologically active agents and drug substances, as well as agrochemical products, ligands, secondary metabolites, polymers and electronic materials. Notwithstanding widespread recent advances in transition metal-catalysed C–H bond activation processes, Pd-catalysed Suzuki–Miyaura coupling (SMC) of (pseudo)halogenated heteroarenes with (het...
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متن کاملSuzuki-Miyaura cross-coupling reaction catalyzed using highly efficient CN-dimeric ortho-palladated complex under microwave irradiation and conventional heating
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عنوان ژورنال:
- Chemical science
دوره 8 1 شماره
صفحات -
تاریخ انتشار 2017